X chromosomes and dosage compensation
نویسندگان
چکیده
منابع مشابه
Dosage Compensation and Demasculinization of X Chromosomes in Drosophila
The X chromosome of Drosophila shows a deficiency of genes with male-biased expression, whereas mammalian X chromosomes are enriched for spermatogenesis genes expressed premeiosis and multicopy testis genes. Meiotic X-inactivation and sexual antagonism can only partly account for these patterns. Here, we show that dosage compensation (DC) in Drosophila may contribute substantially to the deplet...
متن کاملSex chromosomes: Evolving dosage compensation
Dosage compensation of some X-linked genes varies among mammals. Inactivation of an X-linked copy of a gene in females appears to correlate with lack of an active homologue on the Y chromosome, implying that dosage compensation evolves in response to the loss of function of genes on the Y.
متن کاملX-Chromosome dosage compensation.
In mammals, flies, and worms, sex is determined by distinctive regulatory mechanisms that cause males (XO or XY) and females (XX) to differ in their dose of X chromosomes. In each species, an essential X chromosome-wide process called dosage compensation ensures that somatic cells of either sex express equal levels of X-linked gene products. The strategies used to achieve dosage compensation ar...
متن کاملX-Chromosome Dosage Compensation
The X and Y chromosomes of placental and marsupial mammals originated from a pair of autosomes. Ohno hypothesised nearly 50 years ago that the expression levels of X-linked genes should be doubled to compensate for the degeneration of their Y-linked homologues during sex chromosome evolution. The advent of microarray and RNA (ribonucleic acid) sequencing technologies in the past decade prompted...
متن کاملDosage compensation: X-repress yourself
Dosage compensation in Caenorhabditis elegans involves the sex-specific recruitment to the X chromosome of a protein complex, the nature of which suggests that there are mechanistic links between chromosome segregation and global transcriptional regulation.
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ژورنال
عنوان ژورنال: Nature
سال: 1986
ISSN: 0028-0836,1476-4687
DOI: 10.1038/320313b0